Cholestyramine resin 11041-12-6 Cholestyramine CAS NO.11041-12-6

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【Product name】 Cholestyramine
【Chemical name】Cholestyramine Resin; Cholybar; Cholebar; Questran; Quantalan; Colestyramin
【Appearance】 Light yellow or off-white powder,
【CAS No.】 11041-12-6
【Molecular Formula】 C27H46NCl
【Molecular Weight】 385.66878
【EINECS】 234-270-8
【Assay】 98.0%min
【Quality Standard】 Pharm.grade(STP-02-323)
【Packing Size】 10KGS /DRUM, 25KGS /DRUM
【Storage】 Stock solution can be stored below -20℃ for several months. 
 

Cholestyramine also name Cholestyramine Resin, In Europe, the official spelling is Colestyramine. it is an anion exchange resin that sequesters bile salts. It is used for lowering plasma cholesterol, for pruritis associated with elevated bile acids, and for chronic diarrhea associated with Crohn′s disease, ileal resection, diabetes, ileal resection, radiation, and cancer Ippoliti (1998), Yarze (2001). Cholestyramine is not absorbed by the gastrointestinal tract and is completely excreted in the feces. Major adverse effects include constipation and bloating. Numerous cholestyramine drug interactions occur due to binding of the drug by resin in the gastrointestinal tract Mahley and Bersot.

Cholestyramine odorless or some amine smell, and moisture absorption. For obtaining a higher solubility, please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Cholestyramine resin is quite hydrophilic, but insoluble in water.

Quality Standard

Function and application

Cholestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins, which binds bile in the gastrointestinal tract to prevent its reabsorption. Cholestyramine is a strong ion exchange resin, it can exchange its chloride anions with anionic bile acids in the gastrointestinal tract, and bind them strongly in the resin matrix. 

Cholestyramine removes bile acids from the body by forming insoluble complexes with bile acids in the intestine, and then excreted in the feces. As a result of the loss of bile acids, more plasma cholesterol is converted into bile acids in the liver to normalize levels. Cholesterol conversion to bile acids lowers plasma cholesterol levels.

Shanghai Soyoung Biotechnology Inc. a faithful and professional supplier and exporter of healthcare raw materials for pharmacy, nutrition and food industries for years with own laboratory and GMP standard factories.

Shanghai Soyoung has R&D Center and Testing Center, and has international advanced facilities of HPLC, GC, AAS, UV, TLC, LC-MS and IR equipments. 

Shanghai Soyoung has nearly 20 years production experience, it is producing in GMP workshop, each batch pass strict testing before shipment. Strict quality control is performed in every procedure from material sourcing, processing and testing to packing.

Shanghai SOYOUNG onsite assessment conducted by Bureau Veritas commissioned at June 2018. Assessed Supplier of Shanghai SOYOUNG is a faithful and professional supplier of health raw materials in pharmacy, food, cosmetic and other fields for many years, with own laboratories and GMP standard factories.

1. 12 years specialized in health products field.
2. GMP/ISO certificated factories and stable supply chain.
3. Quality first, strictly control before shipments.
4. Custom synthesis by more than 20 professional chemists.
5. Small order,free sample and one step service available.
6. Rapid delivery, 1-6 business days from China warehouse.
7. Support 7 days refund money in case delay shipment.
8. Assessment conducted by Bureau Veritas at 2018.