Tacrolimus powder CAS NO.104987-11-3

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Tacrolimus  powder

Tacrolimus(also FK-506) is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection.

【Product Name】Tacrolimus  
【CAS No.】104987-11-3
【Molecular Formular】C44H69NO12 
【Molecular Weight】804.02
【Assay】99.0% 
【Appearance】White crystalline powder
【Standard】Medical grade
【Packing】25kg/drum or at customer's request.
【Storage】Tight container, protect from light
 

PRODUCT DESCRIPTION

Tacrolimus (fujimycin) was discovered as a potent inhibitor of IL2 production in a targeted search for novel immunosuppressants. Tacrolimus acts by blocking T cell proliferation in vitro by inhibiting the generation of several lymphokines, notably the original target IL-2. Tacrolimus inhibits the activity of FK-506 binding protein, Ca2+-dependent phosphatase and calcineurin, and activates NF-κB through phosphorylation and degradation of IκBα

APPLICATIONS/USAGE

An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release. 2.FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system 3.For use after allogenic organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It was first approved by the FDA in 1994 for use in liver transplantation, this has been extended to include kidney, heart.

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